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Maximum Dose: A maximum of 450 mg per day can be considered for patients who show no clinical improvement after several weeks of treatment at 300 mg per day.
Tablet Options: Dosing above 300 mg per day can be accomplished using the 75- or 100-mg tablets.
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Switching from MAOI Antidepressants: Allow at least 14 days between discontinuation of an MAOI and initiation of Wellbutrin.
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Uses:
Major Depressive Disorder (MDD): Wellbutrin is prescribed to treat MDD.
Seasonal Affective Disorder (SAD): Wellbutrin XL is used for SAD, while Wellbutrin SR is specifically for MDD1.
Dosage Guidelines:
Starting Dose: The recommended starting dose is 200 mg per day, given as 100 mg twice daily.
Gradual Increase: After 3 days, the dose may be increased to 300 mg per day, given as 100 mg three times daily, with at least 6 hours between successive doses.
Maximum Dose: A maximum of 450 mg per day can be considered for patients who show no clinical improvement after several weeks of treatment at 300 mg per day.
Tablet Options: Dosing above 300 mg per day can be accomplished using the 75- or 100-mg tablets.
Maintenance Treatment: Acute episodes of depression require several months or longer of antidepressant drug treatment beyond the initial response.
Hepatic Impairment: In patients with moderate to severe hepatic impairment, the maximum dose is 75 mg per day.
Renal Impairment: Consider reducing the dose and/or frequency in patients with renal impairment.
Switching from MAOI Antidepressants: Allow at least 14 days between discontinuation of an MAOI and initiation of Wellbutrin.
Serious Side Effects: Rare but serious side effects include seizure, liver toxicity, psychosis, and risk of overdose2.
Remember to follow your doctor’s guidance and report any side effects promptly. Wellbutrin has unique features, such as not causing sexual dysfunction and being effective against symptoms of hypersomnia and fatigue3. If you have any concerns, consult your healthcare provider.